RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Twist1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; Immunoblot etc.
Target
NA
Pathway
P53 signaling pathway; RUNX2 signaling pathway; P65 signaling pathway
PubMed ID
Title
"Gene expression profiling of pulmonary fibrosis identifies Twist1 as an antiapoptotic molecular ""rectifier"" of growth factor signaling"
Year
2009
Function
Twist1 promotes survival and accumulation of fibroblasts by shaping their responsiveness to growth factor stimulation.